RapamycinFungusV1, Main, Exploration, bibRecord, 000722

Target of rapamycin signaling mediates vacuolar fragmentation.

Identifieur interne : 000722 ( Main/Exploration ); précédent : 000721; suivant : 000723

Target of rapamycin signaling mediates vacuolar fragmentation.

Auteurs : Bobbiejane Stauffer [États-Unis] ; Ted Powers [États-Unis]

Source :

Current genetics [ 1432-0983 ] ; 2017.

RBID : pubmed:27233284

Descripteurs français

KwdFr :
- Animaux (MeSH), Complexe-1 cible mécanistique de la rapamycine (MeSH), Complexes multiprotéiques (métabolisme), Humains (MeSH), Levures (génétique), Levures (métabolisme), Liaison aux protéines (MeSH), Membranes intracellulaires (métabolisme), Régulation de l'expression des gènes (MeSH), Stress physiologique (MeSH), Sérine-thréonine kinases TOR (métabolisme), Transduction du signal (MeSH), Transport biologique (MeSH), Transport des protéines (MeSH), Vacuoles (métabolisme).
MESH :
- génétique : Levures.
- métabolisme : Complexes multiprotéiques, Levures, Membranes intracellulaires, Sérine-thréonine kinases TOR, Vacuoles.
- Animaux, Complexe-1 cible mécanistique de la rapamycine, Humains, Liaison aux protéines, Régulation de l'expression des gènes, Stress physiologique, Transduction du signal, Transport biologique, Transport des protéines.

English descriptors

KwdEn :
- Animals (MeSH), Biological Transport (MeSH), Gene Expression Regulation (MeSH), Humans (MeSH), Intracellular Membranes (metabolism), Mechanistic Target of Rapamycin Complex 1 (MeSH), Multiprotein Complexes (metabolism), Protein Binding (MeSH), Protein Transport (MeSH), Signal Transduction (MeSH), Stress, Physiological (MeSH), TOR Serine-Threonine Kinases (metabolism), Vacuoles (metabolism), Yeasts (genetics), Yeasts (metabolism).
MESH :
- chemical , metabolism : Multiprotein Complexes, TOR Serine-Threonine Kinases.
- chemical : Mechanistic Target of Rapamycin Complex 1.
- genetics : Yeasts.
- metabolism : Intracellular Membranes, Vacuoles, Yeasts.
- Animals, Biological Transport, Gene Expression Regulation, Humans, Protein Binding, Protein Transport, Signal Transduction, Stress, Physiological.

Abstract

In eukaryotic cells, cellular homeostasis requires that different organelles respond to intracellular as well as environmental signals and modulate their behavior as conditions demand. Understanding the molecular mechanisms required for these changes remains an outstanding goal. One such organelle is the lysosome/vacuole, which undergoes alterations in size and number in response to environmental and physiological stimuli. Changes in the morphology of this organelle are mediated in part by the equilibrium between fusion and fission processes. While the fusion of the yeast vacuole has been studied intensively, the regulation of vacuolar fission remains poorly characterized by comparison. In recent years, a number of studies have incorporated genome-wide visual screens and high-throughput microscopy to identify factors required for vacuolar fission in response to diverse cellular insults, including hyperosmotic and endoplasmic reticulum stress. Available evidence now demonstrates that the rapamycin-sensitive TOR network, a master regulator of cell growth, is required for vacuolar fragmentation in response to stress. Importantly, many of the genes identified in these studies provide new insights into potential links between the vacuolar fission machinery and TOR signaling. Together these advances both extend our understanding of the regulation of vacuolar fragmentation in yeast as well as underscore the role of analogous events in mammalian cells.

DOI: 10.1007/s00294-016-0616-0
PubMed: 27233284
PubMed Central: PMC5124550

Affiliations:

États-Unis

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000A44
to stream Main, to step Curation: 000A44

Le document en format XML

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	Serveur d'exploration sur la rapamycine et les champignons
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Target of rapamycin signaling mediates vacuolar fragmentation.

Target of rapamycin signaling mediates vacuolar fragmentation.

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